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PUBLICATIONS

 

  • Stephens G, Park J, Eagle A, You J, Silva-Perez M, Fu C-H, Choi S, St. Romain C, Sugimoto C, Buffington S, Zheng Y, Costa-Mattioli M, Liu Y, Robison AJ, Chin J (2024) Persistent ∆FosB expression limits recurrent seizure activity and provides neuroprotection in the dentate gyrus of APP mice. Progress in Neurobiology (in press).

  • Clasadonte J*, Deprez T*, Stephens G*, Mairet-Coello G, Cortin P-Y, Boutier M, Frey A, Chin J, Rajman M (2023) ΔFosB is part of a homeostatic mechanism that protects the epileptic brain from further deterioration. Frontiers in Molecular Neuroscience 16:1324922.

  • Fu C-H, You JC, Mohila C, Rissman RA, Yoshor D, Viaene A, Chin J (2023) ∆FosB expression is associated with cognitive impairment in a subgroup of patients with childhood epilepsies. Frontiers in Neurology 14:1331194.

  • Shrestha J, Santerre M, Allen CNS, Arjona SP, Merali C, Mukerjee R, Chitrala KN, Park J, Bagashev A, Bui V, Eugenin EA, Merali S, Kaul M, Chin J, Sawaya BE (2022) HIV-1 gp120 impairs spatial memory through cyclic AMP response element-binding protein. Frontiers in Aging Neuroscience 14:811841. [PMID: 35615594]

  • Jagirdar R, Fu CH, Park J, Corbett B, Seibt FM, Beierlein M, Chin J (2021) Restoring activity in the thalamic reticular nucleus improves sleep architecture and reduces Abeta accumulation in mice. Science Translational Medicine 13:618. [PMID: 34731016]

  • Stephens GS, Fu CH, St. Romain CP, Zheng Y, Botterill JJ, Scharfman HE, Liu Y, Chin J (2020) Genes bound by ∆FosB in different conditions with recurrent seizures regulate similar neuronal functions. Frontiers in Neuroscience 14:472. [PMID: 32536852]

  • O'Malley JJ, Seibt F, Chin J, Beierlein M (2020) TRPM4 conductances in thalamic reticular nucleus neurons generate persistent firing during slow oscillations. Journal of Neuroscience 40(25):4813-4823. [PMID: 32414784]

  • You JC*, Muralidharan K*, Fu CH, Park J, Tosi U, Zhang X, Chin J (2020) Distinct patterns of dentate gyrus cell activation distinguish physiologic from aberrant stimuli. PLoS One 15(5): e0232241. [PMID: 32407421]

  • Chen CJ, Sgritta M, Mays J, Zhou H, Lucero R, Park J, Wang IC, Park JH, Kaipparettu B, Stoica L, Jafar-Nejad P, Rigo F, Chin J, Noebels JL, Costa-Mattioli M (2019) Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency. Nature Medicine 25(11):1684-1690. [PMID: 31636454]

  • Fu C-H*, Iascone D*, Petrof I, Hazra A, Zhang X, Pyfer M, Tosi Y, Corbett B, Cai J, Lee J, Park J, Iacovitti L, Scharfman HE, Enikolopov G, Chin J (2019) Early seizure activity accelerates depletion of hippocampal neural stem cells and impairs spatial discrimination in an Alzheimer’s disease mouse model. Cell Reports 27(13):3741-3751. [PMID: 3124208]

  • You JC*, Stephens GS*, Fu CH, Zhang XH, Liu Y, Chin J (2018). Genome-wide profiling reveals functional diversification of ∆FosB gene targets in the hippocampus of an Alzheimer’s disease mouse model. PLoS One 13(2):e0192508. [PMID 29408867]

  • You JC, Muralidharan K, Park JW, Petrof I, Pyfer MS, Corbett BF, LaFrancois JJ, Zheng Y, Zhang X, Mohila CA, Yoshor D, Rissman RA, Nestler EJ, Scharfman HE, Chin J (2017) Epigenetic suppression of hippocampal calbindin-D28K by ∆FosB drives seizure-related cognitive deficits. Nature Medicine 23(11):1377-1383. [PMID 29035369]

  • Corbett BF, You JC, Zhang X, Pyfer MS, Tosi U, Iascone DM, Petrof I, Hazra A, Fu CH, Stephens GS, Ashok AA, Aschmies S, Zhao L, Nestler EJ, Chin J (2017) ∆FosB regulates gene suppression and cognitive function in a mouse model of Alzheimer’s disease. Cell Reports 20(2):344-355. [PMID 28700937]

  • Stephens GS, You JC, Fu CH, Chin J (2017) Molecular mechanisms of synaptic plasticity and memory and their dysfunction in Alzheimer’s disease. Learning and Memory: A Comprehensive Reference, Ed. John H. Byrne et al., Elsevier, London. pp 1-70.

  • Li X, Zhang Y, Yan Y, Ciric B, Ma CG, Chin J, Curtis M, Rostami A, Zhang GX (2017) LINGO-1-Fc-Transduced neural stem cells are effective therapy for chronic stage experimental autoimmune encephalomyelitis. Mol Neurobiol. 54(6):4365-4378. [PMID: 27344330]

  • Jagirdar R, Chin J (2017) Corticothalamic network dysfunction and Alzheimer’s disease. Brain Research pii: S0006-8993(17)30399-2. [PMID 28919464]

  • Hazra A*, Corbett BF*, You JC, Aschmies SA, Zhao L, Li K, Lepore A, Marsh ED, Chin J (2016) Corticothalamic network dysfunction and behavioral deficits in a mouse model of Alzheimer’s disease Neurobiol Aging 44:96-107. [PMID 27318137]

  • Hazra A, Macolino C, Elliot M, Chin J (2014) Delayed thalamic astrocytosis and disrupted sleep-wake patterns in a pre-clinical model of traumatic brain injury. J. Neurosci. Res. 92(11):1434-1445. [PMID 24964253]

  • Putatunda R, Hala TJ, Chin J, and Lepore AC (2014) Chronic at-level thermal hyperalgesia following rat cervical contusion spinal cord injury is accompanied by neuronal and astrocyte activation and loss of the astrocyte glutamate transporter, GLT-1, in superficial dorsal horn. Brain Res (Epub ahead of print). [PMID 24833066]

  • Iascone DM, Padidam S, Pyfer MS, Zhang X, Zhao L, Chin J (2013) Impairments in neurogenesis are not tightly linked to depressive behavior in Alzheimer’s disease mice. PLoS ONE 8(11):e79651. [PMID 24244537]

  • Chin J, Scharfman HE (2013) Shared cognitive and behavioral impairments in epilepsy and Alzheimer’s disease and potential underlying mechanisms. Epilepsy Behav (epub ahead of print). [PMID: 23321057]

  • Duffy AM, Schaner MJ, Chin J, Scharfman HE (2013) Expression of c-fos in hilar mossy cells of the dentate gyrus in vivo. Hippocampus 23(8):649-655. [PMID 23640815]

  • Corbett BF, Leiser SC, Ling HP, Nagy R, Breysse N, Zhang X, Hazra A, Wood A, Pangalos M, Reinhart P, Chin J (2013) Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer’s disease. J. Neurosci. 33(16):7020-7026. [PMID 23595759]

  • Corbett BF, Chin J (2013) Mouse models in scientific research. Tools and Techniques in the Biomolecular Sciences, Ed. Aysha Divan and Janice Royds, Oxford University Press, Oxford UK, pp 441-465.

  • Yu D, Corbett BF, Yan Y, Zhang G-X, Reinhart P, Cho SJ, Chin J (2012) Early cerebrovascular inflammation in a transgenic mouse model of Alzheimer’s disease. Neurobiol. Aging 33(12):2942-2947. [PMID: 22440674]

  • Brown JT, Chin J, Leiser SC, Nowacki J, Peri R, Osinga HM, Tasneva-Atanasova K, Reinhart P, Pangalos M, Randall AD (2011) Altered intrinsic excitability and reduced Na+ currents in a mouse model Alzheimer’s disease. Neurobiol. Aging 32(11):2109.e1-14. [PMID: 21794952]

  • Roberson ED, Halabisky B, Yoo JW, Yao J, Chin J, Yan F, Wu T, Hamto P, Devidze N, Yu G, Palop JJ, Noebels JL, Mucke L (2011) Tau reduction prevents amyloid-b/Fyn­–dependent cognitive impairment, synaptic abnormalities and epileptiform activity in mouse models of Alzheimer’s disease. J. Neurosci. 31:700-711. [PMID: 21228179]

  • Chin J (2011) Selecting a Mouse Model of Alzheimer’s Disease. Methods in Molecular Biology: Alzheimer’s Disease and Frontotemporal Dementia 670:169-189. Ed. Erik D. Roberson, Humana Press, Totowa, NJ [PMID: 20967591]

  • Meilandt WJ, Yu GQ, Wu T, Chin J, Roberson ED, Palop JJ, Scearce-Levie K, Mucke L. (2008) Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer’s disease. J. Neurosci. 28(19):5007-17. [PMID: 18463254]

  • Chin J, Roberson ED, Mucke L (2008) Molecular aspects of memory dysfunction in Alzheimer's Disease. Learning and Memory: A Comprehensive Reference, Ed. John H. Byrne et al., Elsevier, London, pp 245-293.

  • Chin J, Massaro C, Palop JJ, Thwin MT, Yu GQ, Bien-Ly N, Bender A, and Mucke L (2007) Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer’s disease. J. Neurosci. 27(11):2727-2733. [PMID: 17360894]

  • Palop JJ, Chin J, Roberson ED, Wang J, Thwin M, Bien-Ly N, Yoo J, Ho KO, Yu G-Q, Kreitzer A, Finkbeiner S, Noebels J, Mucke L (2007) Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer’s disease. Neuron 55:697-711. [PMID: 17785178]

  • Venkitaramani DV, Chin J, Netzer WJ, Gouras GK, Lesne S, Malinow R, Lombroso PJ (2007) Beta amyloid modulation of synaptic transmission and plasticity. J. Neurosci. 27(44):11832-7. [PMCID: PMC2671021]

  • Chin J, Liu RY, Cleary LJ, Eskin A, and Byrne JH (2006) TGF-b1-induced long-term changes in neuronal excitability in Aplysia sensory neurons depend on MAPK. J. Neurophys. 95(5):3286-3290. [PMID: 16617179]

  • Rao VR, Pintchovski SA, Chin J, Peebles CL, Mitra S, and Finkbeiner S (2006) AMPA receptors regulate transcription of the plasticity-related immediate-early gene Arc. Nat. Neurosci. 9(7):887-895. [PMID: 16732277]

  • Palop JJ, Chin J, Mucke L. (2006) A network dysfunction perspective on neurodegenerative diseases. Nature 443(7113):768­-73. [PMID: 17051202]

  • Chin J, Palop JJ, Puoliväli J, Massaro C, Bien-Ly N, Masliah E, and Mucke L (2005) Fyn kinase induces synaptic and cognitive dysfunction in a transgenic mouse model of Alzheimer’s disease. J. Neurosci. 25(42):9694-9703. [PMID: 16237174]

  • Palop JJ, Chin J, Bien-Ly N, Massaro C, Yeung B, Yu, GQ, and Mucke L (2005) Vulnerability of dentate granule cells to disruption of Arc expression in human amyloid precursor protein transgenic mice. J. Neurosci. 25(42):9686-9693. [PMID: 16237173]

  • Chin J, Palop JJ, Yu GQ, Kojima N, Masliah E, and Mucke L (2004) Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in amyloid precursor protein transgenic mice. J. Neurosci. 24(19):4692-7. [PMID: 15140940]

  • Khabour O, Katagaya L, Levenson J, Lyons L, Chin J, Byrne JH, and Eskin A (2004) Co-regulation of glutamate uptake and long-term sensitization in Aplysia. J. Neurosci. 24(40):8829-8837. [PMID: 15470149]

  • Palop J, Jones B, Kekonius L, Chin J, Yu GQ, Raber J, Masliah E, and Mucke L (2003) Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits. Proc Natl Acad Sci U S A. 100:9572-9577. [PMCID: PMC170959]

  • Chin J, Angers A, Cleary LJ, Eskin A, and Byrne JH (2002) Transforming growth factor-b1 alters synapsin distribution and modulates synaptic depression in Aplysia. J. Neurosci. 1:22(9):RC220. [PMID: 11978861]

  • Chin J, Burdohan J, Eskin A, and Byrne JH (2002) Inhibitor of glutamate uptake alters synaptic transmission at sensorimotor synapses of Aplysia. J. Neurophys. 87(6):3165-68. [PMID: 12037218]

  • Angers A, Fioravante D, Chin J, Cleary LJ, Bean AJ, and Byrne JH (2002) Aplysia synapsin: Role in short-term plasticity and modulation by 5-HT. J. Neurosci. 1:22(13)5412-22. [PMID: 12097493]

  • Levenson J, Endo S, Kategaya L, Fernandez RI, Brabham DG, Chin J, Byrne JH, and Eskin A (2000)  Long-term regulation of neuronal high-affinity glutamate and glutamine uptake in Aplysia.  Proc. Nat. Acad. Sci. 97(23) 12858-63. [PMID: 11050153]

  • Levenson J, Sherry DM, Dryer L, Chin J, Byrne JH, and Eskin A (2000) Localization of glutamate and glutamate transporters in the sensory neurons of Aplysia. J. Comp. Neurol. 423:121-131. [PMID: 10861541]

  • Chin J, Angers A, Cleary L, Eskin A, and Byrne JH (1999) TGF-b1 in Aplysia: role in long-term changes in the excitability of sensory neurons and distribution of TbR-II-like immunoreactivity. Learning and Memory 6:317-330. [PMID: 10492013]